Understanding DNJ

DNJ (1-deoxynojirimycin) is an active component in mulberry leaf extract. It cannot be digested and absorbed by the body, but will be passed into the large intestine and eventually be discharged from the body.

Understanding DNJ

DNJ (1-deoxynojirimycin) is an active component in mulberry leaf extract. It cannot be digested and absorbed by the body, but will be passed into the large intestine and eventually be discharged from the body.

Because DNJ is structurally similar to glucose, it can act as competitive inhibitors, competing with carbohydrates to bind to α-glucosidase, a digestive enzyme in the small intestines. By delaying the digestion of carbohydrates, the presence of DNJ can then help support healthy blood glucose, balance insulin levels, support weight management, immunity, cardiovascular system and offer natural protection against diabetes.

Because DNJ is structurally similar to glucose, it can act as competitive inhibitors, competing with carbohydrates to bind to α-glucosidase, a digestive enzyme in the small intestines. By delaying the digestion of carbohydrates, the presence of DNJ can then help support healthy blood glucose, balance insulin levels, support weight management, immunity, cardiovascular system and offer natural protection against diabetes.

DNJ Reduces Post Meal Sugar Spikes

After carbohydrates travel down the digestive tract, it is broken down into simple glucose by a digestive enzyme (α-glucosidase) in small intestines. Only then can the glucose get absorbed into the bloodstream. With DNJ act as competitive inhibitors, competing with carbohydrates to bind to α-glucosidase, it helps slow down carbohydrate digestion. This in turn lessens the amount of carbohydrate absorbed into the bloodstream, thereby reducing post-meal blood sugar spikes.  

DNJ Reduces Post Meal Sugar Spikes

After carbohydrates travel down the digestive tract, it is broken down into simple glucose by a digestive enzyme (α-glucosidase) in small intestines. Only then can the glucose get absorbed into the bloodstream. With DNJ act as competitive inhibitors, competing with carbohydrates to bind to α-glucosidase, it helps slow down carbohydrate digestion. This in turn lessens the amount of carbohydrate absorbed into the bloodstream, thereby reducing post-meal blood sugar spikes.  

DNJ Supports Weight Management 

DNJ supports healthy weight management by suppressing lipid build-up in the liver, balancing triglyceride level and lessening the formation of fat cells. 

In an animal test, a group of mice given a fat-rich diet was also administered with DNJ and did not present any weight gain. In comparison, the group of mice only administered with fat-rich diet showed significant weight gain. This proposes the use of DNJ as a dietary supplement for healthy weight management (Food Chem. Toxicol. 75: 1–7 (2015)).

DNJ Supports Weight Management

DNJ supports healthy weight management by suppressing lipid build-up in the liver, balancing triglyceride level and lessening the formation of fat cells.

In an animal test, a group of mice given a fat-rich diet was also administered with DNJ and did not present any weight gain. In comparison, the group of mice only administered with fat-rich diet showed significant weight gain. This proposes the use of DNJ as a dietary supplement for healthy weight management (Food Chem. Toxicol. 75: 1–7 (2015)).

DNJ Offers Cardioprotective Effects

Know first that very-low-density lipoprotein (VLDL) is prone to oxidation and an elevated VLDL levels is a risk factor for arteriosclerosis.

In a study, DNJ-rich mulberry leaf extract (12 mg) was orally administered to nine human subjects three times daily before meals over a period of 12 weeks. On day 12, reduced very-low-densty lipoprotein (VLDL) was observed, suggesting the potential application of mulberry leaf extract in improving blood lipid profile.

DNJ Offers Cardioprotective Effects

Know first that very-low-density lipoprotein (VLDL) is prone to oxidation and an elevated VLDL levels is a risk factor for arteriosclerosis.

In a study, DNJ-rich mulberry leaf extract (12 mg) was orally administered to nine human subjects three times daily before meals over a period of 12 weeks. On day 12, reduced very-low-densty lipoprotein (VLDL) was observed, suggesting the potential application of mulberry leaf extract in improving blood lipid profile.